Moreover, direct evidence for how m 8A2503 alters antibiotic binding sites within the ribosome is lacking. Despite the prevalence of this resistance mechanism, it is poorly understood whether and how bacteria modulate Cfr methylation to adapt to antibiotic pressure. Acquisition of cfr results in resistance to eight classes of ribosome-targeting antibiotics. The rRNA-modifying enzyme Cfr methylates an adenosine nucleotide within the peptidyl transferase center, resulting in the C-8 methylation of A2503 (m 8A2503). Department of Pharmaceutical Chemistry, University of California San Francisco, United States Īlteration of antibiotic binding sites through modification of ribosomal RNA (rRNA) is a common form of resistance to ribosome-targeting antibiotics.Quantitative Biosciences Institute, University of California San Francisco, United States.
Department of Cell and Tissue Biology, University of California San Francisco, United States.Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, United States.Department of Biochemistry and Biophysics, University of California San Francisco, United States.Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, United States.Department of Biomolecular Sciences, Weizmann Institute of Science, Israel.Department of Cellular and Molecular Pharmacology, University of California San Francisco, United States.
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